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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?
|
|---|---|
| Published in |
Acta Neuropathologica Communications, August 2017
|
| DOI | 10.1186/s40478-017-0467-z |
| Pubmed ID | |
| Authors |
Yoon-Ju Lim, Seung-Jae Lee |
| Abstract |
Abnormal protein aggregation has been implicated in neurodegenerative processes in human neurological disorders, such as Alzheimer's disease and Parkinson's disease. Recently, studies have established a novel concept that protein aggregates are transmitted among neuronal cells. By extension, such interneuronal aggregate transmission has been hypothesized to be the underlying mechanism for the pathological and clinical disease progression. However, the precise mechanism of the interneuronal aggregate transmission remains ill-defined. Recent reports have suggested that exosomes, a specific group of extracellular vesicles that are involved in intercellular transfer of cellular macromolecules such as proteins and RNAs, could play an important role in the aggregate transmission among neurons. Here, we review various types of extracellular vesicles and critically evaluate the evidence supporting the role of exosomes in interneuronal aggregate transmission and neurodegeneration. We also discuss the competing mechanisms other than the exosome-mediated transmission. By doing so, we aim to assess the current state of knowledge on the mechanism of interneuronal aggregate transmission and suggest the future directions of research towards understanding the mechanism. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 38% |
| Spain | 1 | 13% |
| Comoros | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 23% |
| Student > Master | 16 | 13% |
| Researcher | 13 | 11% |
| Student > Bachelor | 9 | 7% |
| Student > Doctoral Student | 6 | 5% |
| Other | 18 | 15% |
| Unknown | 31 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 26% |
| Neuroscience | 22 | 18% |
| Agricultural and Biological Sciences | 14 | 12% |
| Medicine and Dentistry | 7 | 6% |
| Chemistry | 5 | 4% |
| Other | 8 | 7% |
| Unknown | 34 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2021.
All research outputs
#4,104,704
of 22,999,744 outputs
Outputs from Acta Neuropathologica Communications
#771
of 1,392 outputs
Outputs of similar age
#72,561
of 315,948 outputs
Outputs of similar age from Acta Neuropathologica Communications
#2
of 15 outputs
Altmetric has tracked 22,999,744 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,392 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.