Title |
Molecular targeting in acute myeloid leukemia
|
---|---|
Published in |
Journal of Translational Medicine, August 2017
|
DOI | 10.1186/s12967-017-1281-x |
Pubmed ID | |
Authors |
Seah H. Lim, Patrycja M. Dubielecka, Vikram M. Raghunathan |
Abstract |
Acute myeloid leukemia (AML) is a heterogenous disease associated with distinct genetic and molecular abnormalities. Somatic mutations result in dysregulation of intracellular signaling pathways, epigenetics, and apoptosis of the leukemia cells. Understanding the basis for the dysregulated processes provides the platform for the design of novel targeted therapy for AML patients. The effort to devise new targeted therapy has been helped by recent advances in methods for high-throughput genomic screening and the availability of computer-assisted techniques for the design of novel agents that are predicted to specifically inhibit the mutant molecules involved in these intracellular events. In this review, we will provide the scientific basis for targeting the dysregulated molecular mechanisms and discuss the agents currently being investigated, alone or in combination with chemotherapy, for treating patients with AML. Successes in molecular targeting will ultimately change the treatment paradigm for the disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Saudi Arabia | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 22% |
Student > Ph. D. Student | 10 | 14% |
Other | 7 | 10% |
Student > Bachelor | 7 | 10% |
Researcher | 5 | 7% |
Other | 14 | 20% |
Unknown | 11 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 21 | 30% |
Medicine and Dentistry | 16 | 23% |
Agricultural and Biological Sciences | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 6 | 9% |
Unknown | 13 | 19% |