Title |
Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling
|
---|---|
Published in |
Stem Cell Research & Therapy, February 2014
|
DOI | 10.1186/scrt417 |
Pubmed ID | |
Authors |
Anna I Arno, Saeid Amini-Nik, Patrick H Blit, Mohammed Al-Shehab, Cassandra Belo, Elaine Herer, Col Homer Tien, Marc G Jeschke |
Abstract |
The prevalence of non-healing wounds is predicted to increase due to the growing aging population. Despite the use of novel skin substitutes and wound dressings, poorly vascularized wound niches impair wound repair. Mesenchymal stem cells (MSCs) have been reported to provide paracrine signals to promote wound healing, but the effect of human Wharton's jelly-derived MSCs (WJ-MSCs) has not yet been described in human normal skin.The aim of this study is to examine the effects of human WJ-MSC paracrine signaling on normal skin fibroblasts in vitro, and in an in vivo preclinical model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Panama | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | <1% |
United States | 1 | <1% |
Russia | 1 | <1% |
Unknown | 201 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 36 | 18% |
Student > Bachelor | 29 | 14% |
Student > Master | 28 | 14% |
Researcher | 23 | 11% |
Student > Doctoral Student | 13 | 6% |
Other | 30 | 15% |
Unknown | 45 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 42 | 21% |
Agricultural and Biological Sciences | 40 | 20% |
Biochemistry, Genetics and Molecular Biology | 32 | 16% |
Engineering | 9 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Other | 20 | 10% |
Unknown | 54 | 26% |