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Sporadic inclusion body myositis: the genetic contributions to the pathogenesis

Overview of attention for article published in Orphanet Journal of Rare Diseases, June 2014
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Title
Sporadic inclusion body myositis: the genetic contributions to the pathogenesis
Published in
Orphanet Journal of Rare Diseases, June 2014
DOI 10.1186/1750-1172-9-88
Pubmed ID
Authors

Qiang Gang, Conceição Bettencourt, Pedro Machado, Michael G Hanna, Henry Houlden

Abstract

Sporadic inclusion body myositis (sIBM) is the commonest idiopathic inflammatory muscle disease in people over 50 years old. It is characterized by slowly progressive muscle weakness and atrophy, with typical pathological changes of inflammation, degeneration and mitochondrial abnormality in affected muscle fibres. The cause(s) of sIBM are still unknown, but are considered complex, with the contribution of multiple factors such as environmental triggers, ageing and genetic susceptibility. This review summarizes the current understanding of the genetic contributions to sIBM and provides some insights for future research in this mysterious disease with the advantage of the rapid development of advanced genetic technology. An international sIBM genetic study is ongoing and whole-exome sequencing will be applied in a large cohort of sIBM patients with the aim of unravelling important genetic risk factors for sIBM.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 52 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 24%
Student > Ph. D. Student 9 17%
Student > Master 7 13%
Student > Doctoral Student 4 7%
Other 3 6%
Other 6 11%
Unknown 12 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 24%
Medicine and Dentistry 10 19%
Biochemistry, Genetics and Molecular Biology 5 9%
Neuroscience 5 9%
Nursing and Health Professions 2 4%
Other 6 11%
Unknown 13 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2014.
All research outputs
#17,722,431
of 22,757,541 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,001
of 2,611 outputs
Outputs of similar age
#155,696
of 228,247 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#32
of 41 outputs
Altmetric has tracked 22,757,541 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,611 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,247 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.