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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, June 2014
|
| DOI | 10.1186/alzrt265 |
| Pubmed ID | |
| Authors |
Yasuko Kitagishi, Atsuko Nakanishi, Yasunori Ogura, Satoru Matsuda |
| Abstract |
Alzheimer's disease (AD) is characterized by the formation of senile plaques and neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that correcting signal dysregulation for Tau phosphorylation in AD may offer a potential therapeutic approach. The PI3K/AKT/GSK-3β pathway has been shown to play a pivotal role in neuroprotection, enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis. This pathway appears to be crucial in AD because it promotes protein hyper-phosphorylation in Tau. Understanding those regulations may provide a better efficacy of new therapeutic approaches. In this review, we summarize advances in the involvement of the PI3K/AKT/GSK-3β pathways in cell signaling of neuronal cells. We also review recent studies on the features of several diets and the signaling pathway involved in AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 171 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 16% |
| Student > Bachelor | 26 | 15% |
| Student > Master | 18 | 11% |
| Researcher | 17 | 10% |
| Student > Postgraduate | 7 | 4% |
| Other | 22 | 13% |
| Unknown | 53 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 13% |
| Agricultural and Biological Sciences | 20 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 12% |
| Medicine and Dentistry | 18 | 11% |
| Biochemistry, Genetics and Molecular Biology | 16 | 9% |
| Other | 21 | 12% |
| Unknown | 53 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2014.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Alzheimer's Research & Therapy
#1,397
of 1,465 outputs
Outputs of similar age
#178,167
of 242,708 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#19
of 19 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,465 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,708 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.