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β cells keep bad epigenetic memories of palmitate

Overview of attention for article published in BMC Medicine, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
6 tweeters

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
15 Mendeley
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Title
β cells keep bad epigenetic memories of palmitate
Published in
BMC Medicine, June 2014
DOI 10.1186/1741-7015-12-104
Pubmed ID
Authors

Delphine Fradin, Pierre Bougnères

Abstract

Palmitic acid, or hexadecanoic acid, a 16-carbon saturated fatty acid (FA), accounts for approximately 38% of the total circulating FA in lean or obese humans. In an article published in BMC Medicine, Hall et al. report that cultured islets from healthy donors, when exposed to palmitate, undergo changes in CpG methylation that are associated with modifications of expression in 290 genes. Their results provide a first look at the mechanisms used by the endocrine pancreas of humans to keep a durable genomic imprint from their exposure to FA that can influence gene expression and possibly cell phenotype in the long term. It is likely that such studies will help understand the epigenetic response of β cells to a disturbed metabolic environment, especially one created by obesity.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 27%
Student > Ph. D. Student 4 27%
Student > Doctoral Student 2 13%
Student > Master 2 13%
Student > Bachelor 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 4 27%
Biochemistry, Genetics and Molecular Biology 3 20%
Agricultural and Biological Sciences 3 20%
Nursing and Health Professions 2 13%
Sports and Recreations 1 7%
Other 1 7%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2014.
All research outputs
#2,003,725
of 16,650,016 outputs
Outputs from BMC Medicine
#1,378
of 2,633 outputs
Outputs of similar age
#24,598
of 191,368 outputs
Outputs of similar age from BMC Medicine
#4
of 5 outputs
Altmetric has tracked 16,650,016 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,633 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.1. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,368 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.