Title |
Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw
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Published in |
Head & Face Medicine, August 2011
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DOI | 10.1186/1746-160x-7-16 |
Pubmed ID | |
Authors |
Luigi Cella, Aldo Oppici, Mariacristina Arbasi, Mauro Moretto, Massimo Piepoli, Daniele Vallisa, Adriano Zangrandi, Camilla Di Nunzio, Luigi Cavanna |
Abstract |
Bisphosphonate - related osteonecrosis of the JAW (BRONJ) is a well known side effect of bisphosphonate therapies in oncologic and non oncologic patients. Since to date no definitive consensus has been reached on the treatment of BRONJ, novel strategies for the prevention, risk reduction and treatment need to be developed. We report a 75 year old woman with stage 3 BRONJ secondary to alendronate and pamidronate treatment of osteoporosis. The patient was unresponsive to recommended treatment of the disease, and her BRONJ was worsening. Since bone marrow stem cells are know as being multipotent and exhibit the potential for differentiation into different cells/tissue lineages, including cartilage, bone and other tissue, we performed autologous bone marrow stem cell transplantation into the BRONJ lesion of the patient. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 1% |
Korea, Republic of | 1 | 1% |
Brazil | 1 | 1% |
Taiwan | 1 | 1% |
Spain | 1 | 1% |
Unknown | 76 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 19% |
Student > Ph. D. Student | 14 | 17% |
Student > Bachelor | 8 | 10% |
Researcher | 6 | 7% |
Student > Doctoral Student | 5 | 6% |
Other | 15 | 19% |
Unknown | 18 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 62% |
Agricultural and Biological Sciences | 4 | 5% |
Engineering | 2 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 1% |
Computer Science | 1 | 1% |
Other | 5 | 6% |
Unknown | 18 | 22% |