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Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

Overview of attention for article published in BMC Cancer, August 2011
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Title
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
Published in
BMC Cancer, August 2011
DOI 10.1186/1471-2407-11-371
Pubmed ID
Authors

Sudhakar Chintharlapalli, Sabitha Papineni, Ping Lei, Satya Pathi, Stephen Safe

Abstract

Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous studies show that BA induces proteasome-dependent degradation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 in prostate cancer cells and this study focused on the mechanism of action of BA in colon cancer cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
France 1 1%
Germany 1 1%
Unknown 80 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 19%
Researcher 14 17%
Student > Ph. D. Student 14 17%
Student > Bachelor 7 8%
Student > Doctoral Student 6 7%
Other 8 10%
Unknown 18 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 23%
Biochemistry, Genetics and Molecular Biology 12 14%
Chemistry 12 14%
Medicine and Dentistry 6 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Other 8 10%
Unknown 21 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2012.
All research outputs
#13,857,114
of 22,651,245 outputs
Outputs from BMC Cancer
#3,183
of 8,235 outputs
Outputs of similar age
#81,506
of 123,973 outputs
Outputs of similar age from BMC Cancer
#42
of 108 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,235 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,973 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.