Title |
CXCR4 Chemokine Receptor Signaling Mediates Pain in Diabetic Neuropathy
|
---|---|
Published in |
Molecular Pain, January 2014
|
DOI | 10.1186/1744-8069-10-42 |
Pubmed ID | |
Authors |
Daniela Maria Menichella, Belmadani Abdelhak, Dongjun Ren, Andrew Shum, Caroline Frietag, Richard J Miller |
Abstract |
Painful Diabetic Neuropathy (PDN) is a debilitating syndrome present in a quarter of diabetic patients that has a substantial impact on their quality of life. Despite this significant prevalence and impact, current therapies for PDN are only partially effective. Moreover, the cellular mechanisms underlying PDN are not well understood. Neuropathic pain is caused by a variety of phenomena including sustained excitability in sensory neurons that reduces the pain threshold so that pain is produced in the absence of appropriate stimuli. Chemokine signaling has been implicated in the pathogenesis of neuropathic pain in a variety of animal models. We therefore tested the hypothesis that chemokine signaling mediates DRG neuronal hyperexcitability in association with PDN. |
X Demographics
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
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Sweden | 1 | 2% |
Unknown | 48 | 98% |
Demographic breakdown
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Student > Master | 8 | 16% |
Researcher | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Librarian | 2 | 4% |
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Unknown | 12 | 24% |
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Other | 7 | 14% |
Unknown | 10 | 20% |