Title |
Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway
|
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Published in |
Journal of Translational Medicine, June 2014
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DOI | 10.1186/1479-5876-12-181 |
Pubmed ID | |
Authors |
Tushar A Shah, Clifford T Mauriello, Pamela S Hair, Amandeep Sandhu, Michael P Stolz, William Thomas Bass, Neel K Krishna, Kenji M Cunnion |
Abstract |
Therapeutic hypothermia is a treatment modality that is increasingly used to improve clinical neurological outcomes for ischemia-reperfusion injury-mediated diseases. Antibody-initiated classical complement pathway activation has been shown to contribute to ischemia-reperfusion injury in multiple disease processes. However, how therapeutic hypothermia affects complement activation is unknown. Our goal was to measure the independent effect of temperature on complement activation, and more specifically, examine the relationship between clinical hypothermia temperatures (31-33°C), and complement activation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 24% |
Student > Master | 6 | 16% |
Student > Bachelor | 4 | 11% |
Other | 3 | 8% |
Researcher | 3 | 8% |
Other | 6 | 16% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 32% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Agricultural and Biological Sciences | 4 | 11% |
Immunology and Microbiology | 2 | 5% |
Psychology | 2 | 5% |
Other | 6 | 16% |
Unknown | 7 | 19% |