Title |
Introduction of non-linear elasticity models for characterization of shape and deformation statistics: application to contractility assessment of isolated adult cardiocytes
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Published in |
BMC Biophysics, August 2011
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DOI | 10.1186/2046-1682-4-17 |
Pubmed ID | |
Authors |
Carlos Bazan, Trevor Hawkins, David Torres-Barba, Peter Blomgren, Paul Paolini |
Abstract |
We are exploring the viability of a novel approach to cardiocyte contractility assessment based on biomechanical properties of the cardiac cells, energy conservation principles, and information content measures. We define our measure of cell contraction as being the distance between the shapes of the contracting cell, assessed by the minimum total energy of the domain deformation (warping) of one cell shape into another. To guarantee a meaningful vis-à-vis correspondence between the two shapes, we employ both a data fidelity term and a regularization term. The data fidelity term is based on nonlinear features of the shapes while the regularization term enforces the compatibility between the shape deformations and that of a hyper-elastic material. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 29% |
Student > Ph. D. Student | 1 | 14% |
Student > Postgraduate | 1 | 14% |
Student > Master | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 2 | 29% |
Computer Science | 1 | 14% |
Chemistry | 1 | 14% |
Agricultural and Biological Sciences | 1 | 14% |
Unknown | 2 | 29% |