Title |
SLC6A4STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study
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Published in |
BMC Genomic Data, June 2014
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DOI | 10.1186/1471-2156-15-78 |
Pubmed ID | |
Authors |
Márcia Regina Pizzo de Castro, Michael Maes, Roberta Losi Guembarovski, Carolina Batista Ariza, Edna Maria Vissoci Reiche, Heber Odebrecht Vargas, Mateus Medonça Vargas, Luiz Gustavo Piccoli de Melo, Seetal Dodd, Michael Berk, Maria Angelica Ehara Watanabe, Sandra Odebrecht Vargas Nunes |
Abstract |
The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current tobacco use disorder, diagnosed according to DSM IV criteria (n = 185), and never-smokers, diagnosed according to CDC criteria (n = 175), were recruited and received 52 weeks of combined pharmacotherapy and cognitive therapy. Successful smoking cessation was defined as exhaled carbon monoxide < 6 ppm. SLC6A4 gene STin2 VNTR polymorphism was assessed using a Multiplex-PCR-based method. At baseline, participants were evaluated using the Fagerström Test for Nicotine Dependence (FTND) and the ASSIST scale. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
Geographical breakdown
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Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 15% |
Student > Ph. D. Student | 6 | 11% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Professor | 4 | 7% |
Other | 12 | 22% |
Unknown | 14 | 25% |
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Psychology | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 4 | 7% |
Unknown | 16 | 29% |