Title |
Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease
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Published in |
Molecular Neurodegeneration, June 2014
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DOI | 10.1186/1750-1326-9-25 |
Pubmed ID | |
Authors |
Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry WM Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel LA van den Hove, Bart PF Rutten |
Abstract |
Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 14% |
Belgium | 1 | 14% |
Netherlands | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 1% |
Canada | 2 | 1% |
United Kingdom | 2 | 1% |
France | 1 | <1% |
Germany | 1 | <1% |
Korea, Republic of | 1 | <1% |
Belgium | 1 | <1% |
Spain | 1 | <1% |
Luxembourg | 1 | <1% |
Other | 0 | 0% |
Unknown | 166 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 24% |
Student > Bachelor | 32 | 18% |
Student > Master | 24 | 13% |
Researcher | 21 | 12% |
Student > Postgraduate | 11 | 6% |
Other | 23 | 13% |
Unknown | 25 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 58 | 33% |
Neuroscience | 32 | 18% |
Biochemistry, Genetics and Molecular Biology | 20 | 11% |
Medicine and Dentistry | 20 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 16 | 9% |
Unknown | 28 | 16% |