Title |
Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis
|
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Published in |
Arthritis Research & Therapy, June 2014
|
DOI | 10.1186/ar4591 |
Pubmed ID | |
Authors |
Bridgette D Furman, Daniel S Mangiapani, Evan Zeitler, Karsyn N Bailey, Phillip H Horne, Janet L Huebner, Virginia B Kraus, Farshid Guilak, Steven A Olson |
Abstract |
Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1(IL-1) and tumor necrosis factor alpha (TNF-alpha), are acutely elevated following joint injury and remain elevated for prolonged periods post-injury. To investigate the role of local and systemic inflammation in the development of post-traumatic arthritis, we targeted both the initial acute local inflammatory response and a prolonged 4 week systemic inflammatory response by inhibiting IL-1 or TNF-alpha following articular fracture in the mouse knee. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 119 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 28 | 23% |
Researcher | 22 | 18% |
Student > Master | 15 | 12% |
Other | 11 | 9% |
Student > Doctoral Student | 10 | 8% |
Other | 21 | 17% |
Unknown | 14 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 31 | 26% |
Engineering | 15 | 12% |
Agricultural and Biological Sciences | 12 | 10% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Immunology and Microbiology | 4 | 3% |
Other | 21 | 17% |
Unknown | 26 | 21% |