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Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

Overview of attention for article published in Arthritis Research & Therapy, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Citations

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142 Dimensions

Readers on

mendeley
121 Mendeley
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2 CiteULike
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Title
Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis
Published in
Arthritis Research & Therapy, June 2014
DOI 10.1186/ar4591
Pubmed ID
Authors

Bridgette D Furman, Daniel S Mangiapani, Evan Zeitler, Karsyn N Bailey, Phillip H Horne, Janet L Huebner, Virginia B Kraus, Farshid Guilak, Steven A Olson

Abstract

Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1(IL-1) and tumor necrosis factor alpha (TNF-alpha), are acutely elevated following joint injury and remain elevated for prolonged periods post-injury. To investigate the role of local and systemic inflammation in the development of post-traumatic arthritis, we targeted both the initial acute local inflammatory response and a prolonged 4 week systemic inflammatory response by inhibiting IL-1 or TNF-alpha following articular fracture in the mouse knee.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Portugal 1 <1%
Unknown 119 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 23%
Researcher 22 18%
Student > Master 15 12%
Other 11 9%
Student > Doctoral Student 10 8%
Other 21 17%
Unknown 14 12%
Readers by discipline Count As %
Medicine and Dentistry 31 26%
Engineering 15 12%
Agricultural and Biological Sciences 12 10%
Biochemistry, Genetics and Molecular Biology 12 10%
Immunology and Microbiology 4 3%
Other 21 17%
Unknown 26 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2018.
All research outputs
#3,277,708
of 25,394,764 outputs
Outputs from Arthritis Research & Therapy
#688
of 3,382 outputs
Outputs of similar age
#31,591
of 242,645 outputs
Outputs of similar age from Arthritis Research & Therapy
#3
of 39 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,382 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,645 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.