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Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets

Overview of attention for article published in Journal of Animal Science and Biotechnology, April 2017
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Title
Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets
Published in
Journal of Animal Science and Biotechnology, April 2017
DOI 10.1186/s40104-017-0159-3
Pubmed ID
Authors

Hans Vergauwen, Jeroen Degroote, Sara Prims, Wei Wang, Erik Fransen, Stefaan De Smet, Christophe Casteleyn, Steven Van Cruchten, Joris Michiels, Chris Van Ginneken

Abstract

In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing. In total, 42 pairs of LBW and NBW piglets from 16 litters suckled the sow until d19 of age or were artificially reared starting at d3 until d19 of age. Blood and tissue samples that were collected after euthanasia at 0, 3, 5, 8 and 19 d of age. Histology, ELISA, and Ussing chamber analysis were used to study proximal and distal small intestine histo-morphology, proliferation, apoptosis, tight junction protein expression, and permeability. Furthermore, small intestine, liver and systemic redox parameters (GSH, GSSG, GSH-Px and MDA) were investigated using HPLC. LBW and NBW artificially reared piglets weighed respectively 40 and 33% more than LBW and NBW sow-reared piglets at d19 (P < 0.01). Transferring piglets to a nursery at d3 resulted in villus atrophy, increased intestinal FD-4 and HRP permeability and elevated GSSG/GSH ratio in the distal small intestine at d5 (P < 0.05). GSH concentrations in the proximal small intestine remained stable, while they decreased in the liver (P < 0.05). From d5 until d19, villus width and crypt depth increased, whereas PCNA, caspase-3, occludin and claudin-3 protein expressions were reduced. GSH, GSSG and permeability recovered in artificially reared piglets (P < 0.05). The results suggest that artificial rearing altered the morphology, permeability and redox state without compromising piglet performance. The observed effects were not depending on birth weight.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Student > Master 6 15%
Professor 5 12%
Student > Bachelor 5 12%
Other 3 7%
Other 8 20%
Unknown 8 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 41%
Veterinary Science and Veterinary Medicine 4 10%
Biochemistry, Genetics and Molecular Biology 2 5%
Nursing and Health Professions 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 3 7%
Unknown 12 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2018.
All research outputs
#17,289,387
of 25,382,440 outputs
Outputs from Journal of Animal Science and Biotechnology
#456
of 904 outputs
Outputs of similar age
#207,047
of 324,441 outputs
Outputs of similar age from Journal of Animal Science and Biotechnology
#12
of 21 outputs
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So far Altmetric has tracked 904 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.