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Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling

Overview of attention for article published in BMC Biotechnology, July 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
twitter
6 X users

Citations

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35 Dimensions

Readers on

mendeley
87 Mendeley
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Title
Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling
Published in
BMC Biotechnology, July 2014
DOI 10.1186/1472-6750-14-60
Pubmed ID
Authors

Akram Ghantous, Richard Saffery, Marie-Pierre Cros, Anne-Louise Ponsonby, Steven Hirschfeld, Carol Kasten, Terence Dwyer, Zdenko Herceg, Hector Hernandez-Vargas

Abstract

Neonatal dried blood spots (DBS) represent an inexpensive method for long-term biobanking worldwide and are considered gold mines for research for several human diseases, including those of metabolic, infectious, genetic and epigenetic origin. However, the utility of DBS is restricted by the limited amount and quality of extractable biomolecules (including DNA), especially for genome wide profiling. Degradation of DNA in DBS often occurs during storage and extraction. Moreover, amplifying small quantities of DNA often leads to a bias in subsequent data, particularly in methylome profiles. Thus it is important to develop methodologies that maximize both the yield and quality of DNA from DBS for downstream analyses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Netherlands 1 1%
Norway 1 1%
Unknown 84 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 20%
Student > Master 14 16%
Researcher 12 14%
Student > Bachelor 7 8%
Professor 6 7%
Other 15 17%
Unknown 16 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 25%
Biochemistry, Genetics and Molecular Biology 15 17%
Medicine and Dentistry 8 9%
Chemistry 5 6%
Engineering 4 5%
Other 15 17%
Unknown 18 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2016.
All research outputs
#2,870,279
of 22,758,248 outputs
Outputs from BMC Biotechnology
#109
of 935 outputs
Outputs of similar age
#29,899
of 227,590 outputs
Outputs of similar age from BMC Biotechnology
#2
of 27 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 935 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.