Title |
Human immunodeficiency virus Tat associates with a specific set of cellular RNAs
|
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Published in |
Retrovirology, July 2014
|
DOI | 10.1186/1742-4690-11-53 |
Pubmed ID | |
Authors |
Russell D Bouwman, Anne Palser, Chris M Parry, Eve Coulter, Jane Rasaiyaah, Paul Kellam, Richard G Jenner |
Abstract |
Human Immunodeficiency Virus 1 (HIV-1) exhibits a wide range of interactions with the host cell but whether viral proteins interact with cellular RNA is not clear. A candidate interacting factor is the trans-activator of transcription (Tat) protein. Tat is required for expression of virus genes but activates transcription through an unusual mechanism; binding to an RNA stem-loop, the transactivation response element (TAR), with the host elongation factor P-TEFb. HIV-1 Tat has also been shown to alter the expression of host genes during infection, contributing to viral pathogenesis but, whether Tat also interacts with cellular RNAs is unknown. |
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Venezuela, Bolivarian Republic of | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 33% |
Student > Ph. D. Student | 8 | 27% |
Student > Bachelor | 2 | 7% |
Student > Master | 2 | 7% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 13% |
Unknown | 3 | 10% |
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Medicine and Dentistry | 2 | 7% |
Other | 3 | 10% |
Unknown | 2 | 7% |