Title |
The effects of opioids on HIV reactivation in latently-infected T-lymphoblasts
|
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Published in |
AIDS Research and Therapy, July 2014
|
DOI | 10.1186/1742-6405-11-17 |
Pubmed ID | |
Authors |
Johannes Prottengeier, Eleni Koutsilieri, Carsten Scheller |
Abstract |
Opioids may have effects on susceptibility to HIV-infection, viral replication and disease progression. Injecting drug users (IDU), as well as anyone receiving opioids for anesthesia and analgesia may suffer the clinical consequences of such interactions. There is conflicting data between in vitro experiments showing an enhancing effect of opioids on HIV replication and clinical data, mostly showing no such effect. For clarification we studied the effects of the opioids heroin and morphine on HIV replication in cultured CD4-positive T cells at several concentrations and we related the observed effects with the relevant reached plasma concentrations found in IDUs. |
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Unknown | 4 | 50% |
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Mendeley readers
Geographical breakdown
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