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Influence of growth hormone treatment on radiographic indices of the spine: propensity-matched analysis

Overview of attention for article published in Journal of Orthopaedic Surgery and Research, September 2017
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Title
Influence of growth hormone treatment on radiographic indices of the spine: propensity-matched analysis
Published in
Journal of Orthopaedic Surgery and Research, September 2017
DOI 10.1186/s13018-017-0630-z
Pubmed ID
Authors

Yeo-Hon Yun, Soon-Sun Kwon, Youngdo Koh, Dong-Jun Kim, Jonghyun Ahn, Seung Yeol Lee

Abstract

We performed this study to investigate the influence of recombinant human growth hormone (rhGH) therapy on radiographic indices of the spine using propensity-matched analysis. Patients with idiopathic short stature who had undergone both growth hormone therapy and whole-spine radiographs more than twice prior to 15 years of age were included in the patient group. Other patients who had undergone whole-spine radiographs more than twice prior to the same age during regular checkups for idiopathic scoliosis formed the control group. Propensity-matched analysis was performed to reduce the selection bias. The scoliosis Cobb angle, coronal balance, apical vertebral translation, apical rotation, and pelvic obliquity were measured from the radiographs taken at the periodic follow-ups. The rate of progression of the measurements was adjusted by multiple factors using a linear mixed model with sex as the fixed effect and age and each subject as the random effects. Using a propensity-matched analysis, 48 patients were finally included in both groups. The scoliosis Cobb angle increased by 1.0° (p < 0.001) per year in the patient group, whereas there was no significant annual change in the control group (p = 0.496). Female patients showed a greater scoliosis Cobb angle (1.8°, p = 0.039) compared with male patients. There was no significant difference between the patient and control groups in coronal balance (p = 0.264). Apical vertebral translation per year was increased by 1.2 mm (p < 0.001) in the patient group and 0.5 mm in the control group (p = 0.003). Radiographic examination revealed that growth hormone therapy for idiopathic short stature affected the progression of the scoliosis Cobb angle and apical vertebral translation on the coronal plane. Physicians should be aware that annual follow-up is required to evaluate the change in the curvature of the spine in patients undergoing rhGH treatment.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 18%
Professor > Associate Professor 2 18%
Student > Doctoral Student 1 9%
Unspecified 1 9%
Student > Master 1 9%
Other 3 27%
Unknown 1 9%
Readers by discipline Count As %
Medicine and Dentistry 6 55%
Unspecified 1 9%
Nursing and Health Professions 1 9%
Engineering 1 9%
Unknown 2 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2017.
All research outputs
#16,542,034
of 20,568,640 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#819
of 1,238 outputs
Outputs of similar age
#217,992
of 288,809 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#1
of 1 outputs
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