Title |
Raphe serotonergic neurons modulate genioglossus corticomotor activity in intermittent hypoxic rats
|
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Published in |
Respiratory Research, July 2014
|
DOI | 10.1186/1465-9921-15-76 |
Pubmed ID | |
Authors |
Jiao Su, Wei Wang, Longfeng Sun, Ting Li, Delei Kong, Jian Kang |
Abstract |
Genioglossus activity is greater during wakefulness but decreases to a weaker state during sleep in obstructive sleep apnea syndrome (OSAS) patients, compared to healthy subjects. Previous studies suggested that the corticomotor control of the genioglossus was modified in OSAS patients. Intermittent hypoxia (IH), the typical pathophysiological change in OSAS, can induce genioglossus facilitation. The serotonergic neurons of the raphe dorsal (DRN) and magnus nuclei (RMg) are responsive to hypoxia and play important roles in the control of the genioglossus. However, it remains unknown whether DRN and RMg serotonergic neurons are responsible for the facilitated corticomotor activity of the genioglossus during IH. This study explored the influence of IH on the corticomotor activity of the genioglossus by transcranial magnetic stimulation (TMS), and the role of DRN and RMg serotonergic neurons in this effect. |
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