Title |
Increased fracture rate in women with breast cancer: a review of the hidden risk
|
---|---|
Published in |
BMC Cancer, August 2011
|
DOI | 10.1186/1471-2407-11-384 |
Pubmed ID | |
Authors |
Jean-Jacques Body |
Abstract |
Women with breast cancer, particularly individuals diagnosed at a relatively early age, have an increased incidence of fractures. Fractures can have serious clinical consequences including the need for major surgery, increased morbidity and mortality, increased cost of disease management, and reduced quality of life for patients. The primary cause of the increased fracture risk appears to be an accelerated decrease in bone mineral density (BMD) resulting from the loss of estrogenic signaling that occurs with most treatments for breast cancer, including aromatase inhibitors. However, factors other than BMD levels alone may influence treatment decisions to reduce fracture risk in this setting. Our purpose is to review current evidence for BMD loss and fracture risk during treatment for breast cancer and discuss pharmacologic means to reduce this risk. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 87 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 15 | 17% |
Student > Ph. D. Student | 12 | 14% |
Student > Postgraduate | 9 | 10% |
Other | 8 | 9% |
Student > Master | 7 | 8% |
Other | 10 | 11% |
Unknown | 27 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 38 | 43% |
Nursing and Health Professions | 7 | 8% |
Agricultural and Biological Sciences | 3 | 3% |
Engineering | 2 | 2% |
Materials Science | 2 | 2% |
Other | 7 | 8% |
Unknown | 29 | 33% |