Title |
In vivo transport of Gd-DTPA2- into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
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Published in |
BMC Musculoskeletal Disorders, July 2014
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DOI | 10.1186/1471-2474-15-226 |
Pubmed ID | |
Authors |
Ulf Sigurdsson, Carl Siversson, Eveliina Lammentausta, Jonas Svensson, Carl-Johan Tiderius, Leif E Dahlberg |
Abstract |
Impaired stability is a risk factor in knee osteoarthritis (OA), where the whole joint and not only the joint cartilage is affected. The meniscus provides joint stability and is involved in the early pathological progress of OA. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been used to identify pre-radiographic changes in the cartilage in OA, but has been used less commonly to examine the meniscus, and then using only a double dose of the contrast agent. The purpose of this study was to enable improved early OA diagnosis by investigate the temporal contrast agent distribution in the meniscus and femoral cartilage simultaneously, in healthy volunteers, using 3D dGEMRIC at two different doses of the contrast agent Gd-DTPA2-. |
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