Title |
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds
|
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Published in |
Malaria Journal, January 2014
|
DOI | 10.1186/1475-2875-13-2 |
Pubmed ID | |
Authors |
Sean R Marcsisin, Jason C Sousa, Gregory A Reichard, Diana Caridha, Qiang Zeng, Norma Roncal, Ronan McNulty, Julio Careagabarja, Richard J Sciotti, Jason W Bennett, Victor E Zottig, Gregory Deye, Qigui Li, Lisa Read, Mark Hickman, N P Dhammika Nanayakkara, Larry A Walker, Bryan Smith, Victor Melendez, Brandon S Pybus |
Abstract |
Tafenoquine (TQ) is an 8-aminoquinoline (8AQ) that has been tested in several Phase II and Phase III clinical studies and is currently in late stage development as an anti-malarial prophylactic agent. NPC-1161B is a promising 8AQ in late preclinical development. It has recently been reported that the 8AQ drug primaquine requires metabolic activation by CYP 2D6 for efficacy in humans and in mice, highlighting the importance of pharmacogenomics in the target population when administering primaquine. A logical follow-up study was to determine whether CYP 2D activation is required for other compounds in the 8AQ structural class. |
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Geographical breakdown
Country | Count | As % |
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Australia | 8 | 22% |
United Kingdom | 5 | 14% |
United States | 2 | 6% |
Canada | 1 | 3% |
Curaçao | 1 | 3% |
New Zealand | 1 | 3% |
France | 1 | 3% |
Unknown | 17 | 47% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 30 | 83% |
Scientists | 2 | 6% |
Science communicators (journalists, bloggers, editors) | 2 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Unknown | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
India | 1 | 1% |
Unknown | 84 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 19% |
Student > Ph. D. Student | 15 | 17% |
Student > Master | 11 | 13% |
Student > Bachelor | 9 | 10% |
Other | 8 | 9% |
Other | 12 | 14% |
Unknown | 15 | 17% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 16 | 19% |
Chemistry | 9 | 10% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Other | 7 | 8% |
Unknown | 16 | 19% |