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Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption

Overview of attention for article published in Stem Cell Research & Therapy, December 2010
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Title
Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption
Published in
Stem Cell Research & Therapy, December 2010
DOI 10.1186/scrt36
Pubmed ID
Authors

Tom N Grammatopoulos, Susan M Jones, Masami Yoshimura, Brian R Hoover, Mita Das, Evan Y Snyder, Gaynor A Larson, Nancy R Zahniser, Boris Tabakoff, WMichael Zawada

Abstract

Regulated neurotransmitter actions in the mammalian central nervous system determine brain function and control peripheral organs and behavior. Although drug-seeking behaviors, including alcohol consumption, depend on central neurotransmission, modification of neurotransmitter actions in specific brain nuclei remains challenging. Herein, we report a novel approach for neurotransmission modification in vivo by transplantation of stem cells engineered to take up the neurotransmitter dopamine (DA) efficiently through the action of the human dopamine transporter (hDAT). As a functional test in mice, we used voluntary alcohol consumption, which is known to release DA in nucleus accumbens (NAC), an event hypothesized to help maintain drug-seeking behavior. We reasoned that reducing extracellular DA levels, by engrafting into NAC DA-sequestering stem cells expressing hDAT, would alter alcohol intake.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Researcher 5 24%
Student > Doctoral Student 3 14%
Student > Bachelor 2 10%
Student > Master 2 10%
Other 2 10%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 24%
Neuroscience 4 19%
Biochemistry, Genetics and Molecular Biology 3 14%
Medicine and Dentistry 2 10%
Nursing and Health Professions 1 5%
Other 4 19%
Unknown 2 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2010.
All research outputs
#20,145,561
of 22,651,245 outputs
Outputs from Stem Cell Research & Therapy
#2,036
of 2,410 outputs
Outputs of similar age
#169,764
of 180,074 outputs
Outputs of similar age from Stem Cell Research & Therapy
#6
of 6 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,410 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,074 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.