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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Host stress hormone norepinephrine stimulates pneumococcal growth, biofilm formation and virulence gene expression
|
|---|---|
| Published in |
BMC Microbiology, July 2014
|
| DOI | 10.1186/1471-2180-14-180 |
| Pubmed ID | |
| Authors |
Sara Sandrini, Fayez Alghofaili, Primrose Freestone, Hasan Yesilkaya |
| Abstract |
Host signals are being shown to have a major impact on the bacterial phenotype. One of them is the endogenously produced catecholamine stress hormones, which are also used therapeutically as inotropes. Recent work form our laboratories have found that stress hormones can markedly increase bacterial growth and virulence. This report reveals that Streptococcus pneumoniae, a commensal that can also be a major cause of community acquired and nosocomial pneumonia, is highly inotrope responsive. Therapeutic levels of the stress hormone norepinephrine increased pneumococcal growth via a mechanism involving provision of iron from serum-transferrin and inotrope uptake, as well as enhancing expression of key genes in central metabolism and virulence. Collectively, our data suggests that Streptococcus pneumoniae recognises host stress as an environmental cue to initiate growth and pathogenic processes. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 29% |
| Saudi Arabia | 1 | 14% |
| Venezuela, Bolivarian Republic of | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Scientists | 2 | 29% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| Denmark | 1 | 1% |
| Unknown | 71 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 16% |
| Student > Bachelor | 12 | 16% |
| Researcher | 11 | 15% |
| Student > Ph. D. Student | 10 | 14% |
| Student > Postgraduate | 5 | 7% |
| Other | 12 | 16% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 34% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Immunology and Microbiology | 8 | 11% |
| Medicine and Dentistry | 7 | 10% |
| Neuroscience | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2020.
All research outputs
#6,931,370
of 25,402,889 outputs
Outputs from BMC Microbiology
#719
of 3,492 outputs
Outputs of similar age
#61,857
of 242,120 outputs
Outputs of similar age from BMC Microbiology
#11
of 62 outputs
Altmetric has tracked 25,402,889 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,492 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,120 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.