Title |
A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis
|
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Published in |
BMC Cancer, August 2011
|
DOI | 10.1186/1471-2407-11-377 |
Pubmed ID | |
Authors |
Robert K Dearth, Isere Kuiatse, Yu-Fen Wang, Lan Liao, Susan G Hilsenbeck, Powel H Brown, Jianming Xu, Adrian V Lee |
Abstract |
Epidemiological evidence suggests that moderately elevated levels of circulating insulin-like growth factor-I (IGF-I) are associated with increased risk of breast cancer in women. How circulating IGF-I may promote breast cancer incidence is unknown, however, increased IGF-I signaling is linked to trastuzumab resistance in ErbB2 positive breast cancer. Few models have directly examined the effect of moderately high levels of circulating IGF-I on breast cancer initiation and progression. The purpose of this study was to assess the ability of circulating IGF-I to independently initiate mammary tumorigenesis and/or accelerate the progression of ErbB2 mediated mammary tumor growth. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 40% |
Student > Ph. D. Student | 4 | 20% |
Professor > Associate Professor | 2 | 10% |
Student > Master | 2 | 10% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 35% |
Medicine and Dentistry | 5 | 25% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Physics and Astronomy | 1 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 3 | 15% |