Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina

RT @renesugar: BH4 deficiency is associated with augmented inflammation and microvascular degeneration in the retina https://t.co/qJIX84UY…

https://t.co/qJIX84UYkz "BH4 supplementation was able to suppress the excessive antiangiogenic activity of TSP-1 and modulate the inflammatory activity of microglial cells under hyperoxic conditions."

https://t.co/qJIX84UYkz "GTPCH I overexpression, the rate-limiting enzyme of BH4 synthesis, rescues the regenerative capacity of diabetic-impaired endothelial progenitor cells by suppressing oxidative stress and TSP-1 levels"

BH4 deficiency is associated with augmented inflammation and microvascular degeneration in the retina https://t.co/qJIX84UYkz "deficiency in BH4 can cause the uncoupling of eNOS, leading to a reduction in NO bioavailability & increased reactive oxyge