Title |
Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction
|
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Published in |
BMC Clinical Pathology, July 2014
|
DOI | 10.1186/1472-6890-14-33 |
Pubmed ID | |
Authors |
Matthew D Krasowski, Denny Drees, Cory S Morris, Jon Maakestad, John L Blau, Sean Ekins |
Abstract |
Immunoassays are widely used in clinical laboratories for measurement of plasma/serum concentrations of steroid hormones such as cortisol and testosterone. Immunoassays can be performed on a variety of standard clinical chemistry analyzers, thus allowing even small clinical laboratories to do analysis on-site. One limitation of steroid hormone immunoassays is interference caused by compounds with structural similarity to the target steroid of the assay. Interfering molecules include structurally related endogenous compounds and their metabolites as well as drugs such as anabolic steroids and synthetic glucocorticoids. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Unknown | 171 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 15% |
Student > Bachelor | 25 | 14% |
Researcher | 22 | 13% |
Student > Master | 18 | 10% |
Other | 13 | 7% |
Other | 26 | 15% |
Unknown | 44 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 21% |
Biochemistry, Genetics and Molecular Biology | 22 | 13% |
Agricultural and Biological Sciences | 19 | 11% |
Chemistry | 18 | 10% |
Veterinary Science and Veterinary Medicine | 5 | 3% |
Other | 20 | 11% |
Unknown | 54 | 31% |