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Methods for the field evaluation of quantitative G6PD diagnostics: a review

Overview of attention for article published in Malaria Journal, September 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)

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6 tweeters
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1 Facebook page

Citations

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36 Dimensions

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74 Mendeley
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Title
Methods for the field evaluation of quantitative G6PD diagnostics: a review
Published in
Malaria Journal, September 2017
DOI 10.1186/s12936-017-2017-3
Pubmed ID
Authors

Benedikt Ley, Germana Bancone, Lorenz von Seidlein, Kamala Thriemer, Jack S. Richards, Gonzalo J. Domingo, Ric N. Price

Abstract

Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at risk of severe haemolysis following the administration of 8-aminoquinoline compounds. Primaquine is the only widely available 8-aminoquinoline for the radical cure of Plasmodium vivax. Tafenoquine is under development with the potential to simplify treatment regimens, but point-of-care (PoC) tests will be needed to provide quantitative measurement of G6PD activity prior to its administration. There is currently a lack of appropriate G6PD PoC tests, but a number of new tests are in development and are likely to enter the market in the coming years. As these are implemented, they will need to be validated in field studies. This article outlines the technical details for the field evaluation of novel quantitative G6PD diagnostics such as sample handling, reference testing and statistical analysis. Field evaluation is based on the comparison of paired samples, including one sample tested by the new assay at point of care and one sample tested by the gold-standard reference method, UV spectrophotometry in an established laboratory. Samples can be collected as capillary or venous blood; the existing literature suggests that potential differences in capillary or venous blood are unlikely to affect results substantially. The collection and storage of samples is critical to ensure preservation of enzyme activity, it is recommended that samples are stored at 4 °C and testing occurs within 4 days of collection. Test results can be visually presented as scatter plot, Bland-Altman plot, and a histogram of the G6PD activity distribution of the study population. Calculating the adjusted male median allows categorizing results according to G6PD activity to calculate standard performance indicators and to perform receiver operating characteristic (ROC) analysis.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 18%
Researcher 13 18%
Student > Bachelor 11 15%
Student > Master 7 9%
Student > Postgraduate 6 8%
Other 10 14%
Unknown 14 19%
Readers by discipline Count As %
Medicine and Dentistry 20 27%
Biochemistry, Genetics and Molecular Biology 15 20%
Agricultural and Biological Sciences 10 14%
Nursing and Health Professions 2 3%
Business, Management and Accounting 2 3%
Other 10 14%
Unknown 15 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2018.
All research outputs
#3,323,527
of 12,942,974 outputs
Outputs from Malaria Journal
#1,084
of 3,801 outputs
Outputs of similar age
#82,194
of 266,071 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 12,942,974 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,801 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,071 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them