Title |
Cerebral microsporidiosis manifesting as progressive multifocal leukoencephalopathy in an HIV-infected individual - a case report
|
---|---|
Published in |
AIDS Research and Therapy, July 2014
|
DOI | 10.1186/1742-6405-11-20 |
Pubmed ID | |
Authors |
Maude Loignon, Louise-Geneviève Labrecque, Céline Bard, Yves Robitaille, Emil Toma |
Abstract |
Microsporidia have become increasingly recognized as opportunistic pathogens since the genesis of the AIDS epidemic. The incidence of microsporidiosis has decreased with the advent of combination antiretroviral therapy but it is frequently reported in non-HIV immunosuppressed patients and as a latent infection in immunocompetent individuals. Herein, we describe an HIV-infected male (46 years) with suspected progressive multifocal leukoencephalopathy that has not responded to optimal antiretroviral therapy, steroids, or cidofovir. Post-mortem examination revealed cerebral microsporidiosis. No diagnostic clue however, was found when the patient was alive. This report underscores the need for physicians to consider microsporidiosis (potentially affecting the brain) when no other etiology is established both in HIV, non-HIV immunosuppressed patients and in immunocompetent individuals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 16% |
Student > Master | 3 | 9% |
Student > Bachelor | 2 | 6% |
Lecturer | 1 | 3% |
Other | 1 | 3% |
Other | 5 | 16% |
Unknown | 15 | 47% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 31% |
Immunology and Microbiology | 3 | 9% |
Nursing and Health Professions | 1 | 3% |
Unspecified | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 1 | 3% |
Unknown | 15 | 47% |