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The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation

Overview of attention for article published in Epigenetics & Chromatin, June 2014
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

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1 X user
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1 patent

Citations

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67 Dimensions

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91 Mendeley
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Title
The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation
Published in
Epigenetics & Chromatin, June 2014
DOI 10.1186/1756-8935-7-12
Pubmed ID
Authors

Alissa Minkovsky, Anna Sahakyan, Elyse Rankin-Gee, Giancarlo Bonora, Sanjeet Patel, Kathrin Plath

Abstract

X chromosome inactivation (XCI) is a developmental program of heterochromatin formation that initiates during early female mammalian embryonic development and is maintained through a lifetime of cell divisions in somatic cells. Despite identification of the crucial long non-coding RNA Xist and involvement of specific chromatin modifiers in the establishment and maintenance of the heterochromatin of the inactive X chromosome (Xi), interference with known pathways only partially reactivates the Xi once silencing has been established. Here, we studied ATF7IP (MCAF1), a protein previously characterized to coordinate DNA methylation and histone H3K9 methylation through interactions with the methyl-DNA binding protein MBD1 and the histone H3K9 methyltransferase SETDB1, as a candidate maintenance factor of the Xi.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 91 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 30%
Researcher 21 23%
Student > Master 9 10%
Student > Bachelor 8 9%
Student > Doctoral Student 4 4%
Other 13 14%
Unknown 9 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 38%
Biochemistry, Genetics and Molecular Biology 32 35%
Medicine and Dentistry 5 5%
Immunology and Microbiology 4 4%
Computer Science 1 1%
Other 3 3%
Unknown 11 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2022.
All research outputs
#7,665,659
of 23,862,416 outputs
Outputs from Epigenetics & Chromatin
#310
of 583 outputs
Outputs of similar age
#72,070
of 231,211 outputs
Outputs of similar age from Epigenetics & Chromatin
#2
of 10 outputs
Altmetric has tracked 23,862,416 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 583 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,211 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.