Title |
The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation
|
---|---|
Published in |
Epigenetics & Chromatin, June 2014
|
DOI | 10.1186/1756-8935-7-12 |
Pubmed ID | |
Authors |
Alissa Minkovsky, Anna Sahakyan, Elyse Rankin-Gee, Giancarlo Bonora, Sanjeet Patel, Kathrin Plath |
Abstract |
X chromosome inactivation (XCI) is a developmental program of heterochromatin formation that initiates during early female mammalian embryonic development and is maintained through a lifetime of cell divisions in somatic cells. Despite identification of the crucial long non-coding RNA Xist and involvement of specific chromatin modifiers in the establishment and maintenance of the heterochromatin of the inactive X chromosome (Xi), interference with known pathways only partially reactivates the Xi once silencing has been established. Here, we studied ATF7IP (MCAF1), a protein previously characterized to coordinate DNA methylation and histone H3K9 methylation through interactions with the methyl-DNA binding protein MBD1 and the histone H3K9 methyltransferase SETDB1, as a candidate maintenance factor of the Xi. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 30% |
Researcher | 21 | 23% |
Student > Master | 9 | 10% |
Student > Bachelor | 8 | 9% |
Student > Doctoral Student | 4 | 4% |
Other | 13 | 14% |
Unknown | 9 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 38% |
Biochemistry, Genetics and Molecular Biology | 32 | 35% |
Medicine and Dentistry | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Computer Science | 1 | 1% |
Other | 3 | 3% |
Unknown | 11 | 12% |