Title |
The effects of phenylalanine on exercise-induced fat oxidation: a preliminary, double-blind, placebo-controlled, crossover trial
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Published in |
Journal of the International Society of Sports Nutrition, April 2022
|
DOI | 10.1186/s12970-017-0191-x |
Pubmed ID | |
Authors |
Keisuke Ueda, Chiaki Sanbongi, Makoto Yamaguchi, Shuji Ikegami, Takafumi Hamaoka, Satoshi Fujita |
Abstract |
When combined with exercise, dietary amino acid (AA) supplementation is an effective method for accelerating fat mobilization. However, the effects of single AAs combined with exercise on fat oxidation remains unclear. We hypothesized that consumption of a specific amino acid, L- phenylalanine, may result in the secretion of glucagon, and when combined with exercise may promote fat oxidation. Six healthy, active male volunteers were randomized in a crossover study to ingest either phenylalanine (3 g/dose) or placebo. Thirty minutes after ingestion each subject performed workload trials on a cycle ergometer for 1 h at 50% of maximal oxygen consumption. Oral intake of phenylalanine caused a significant increase in the concentrations of plasma glycerol and glucagon during exercise. The respiratory exchange ratio was also decreased significantly following ingestion of phenylalanine. These results suggested that pre-exercise supplementation of phenylalanine may stimulate whole body fat oxidation. No serious or study-related adverse events were observed. UMIN000027502 Registered 26 May 2017. Restrospectively registered. |
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Country | Count | As % |
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United States | 9 | 27% |
Japan | 2 | 6% |
Australia | 2 | 6% |
Italy | 1 | 3% |
United Kingdom | 1 | 3% |
Unknown | 18 | 55% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 6 | 18% |
Scientists | 3 | 9% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 17% |
Student > Ph. D. Student | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Researcher | 6 | 8% |
Student > Postgraduate | 5 | 7% |
Other | 14 | 20% |
Unknown | 21 | 30% |
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Nursing and Health Professions | 11 | 15% |
Medicine and Dentistry | 10 | 14% |
Sports and Recreations | 7 | 10% |
Computer Science | 1 | 1% |
Other | 3 | 4% |
Unknown | 27 | 38% |