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The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma

Overview of attention for article published in Journal for Immunotherapy of Cancer, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent
facebook
2 Facebook pages

Citations

dimensions_citation
122 Dimensions

Readers on

mendeley
84 Mendeley
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Title
The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma
Published in
Journal for Immunotherapy of Cancer, January 2014
DOI 10.1186/2051-1426-2-21
Pubmed ID
Authors

Minghui Li, Aaron R Bolduc, Md Hoda, Denise N Gamble, Sarah-Bianca Dolisca, Anna K Bolduc, Kelly Hoang, Claire Ashley, David McCall, Amyn M Rojiani, Bernard L Maria, Olivier Rixe, Tobey J MacDonald, Peter S Heeger, Andrew L Mellor, David H Munn, Theodore S Johnson

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an enzyme with immune-suppressive properties that is commonly exploited by tumors to evade immune destruction. Anti-tumor T cell responses can be initiated in solid tumors, but are immediately suppressed by compensatory upregulation of immunological checkpoints, including IDO. In addition to these known effects on the adaptive immune system, we previously showed widespread, T cell-dependent complement deposition during allogeneic fetal rejection upon maternal treatment with IDO-blockade. We hypothesized that IDO protects glioblastoma from the full effects of chemo-radiation therapy by preventing vascular activation and complement-dependent tumor destruction.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Belgium 1 1%
Unknown 82 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 31%
Student > Ph. D. Student 21 25%
Student > Bachelor 8 10%
Other 3 4%
Student > Master 3 4%
Other 6 7%
Unknown 17 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 26%
Medicine and Dentistry 17 20%
Chemistry 6 7%
Immunology and Microbiology 5 6%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 9 11%
Unknown 21 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2022.
All research outputs
#5,147,333
of 21,392,919 outputs
Outputs from Journal for Immunotherapy of Cancer
#1,095
of 2,609 outputs
Outputs of similar age
#46,060
of 206,189 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#1
of 1 outputs
Altmetric has tracked 21,392,919 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,609 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,189 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them