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The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma

Overview of attention for article published in Journal for Immunotherapy of Cancer, July 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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3 X users
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1 patent
facebook
2 Facebook pages

Citations

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133 Dimensions

Readers on

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98 Mendeley
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Title
The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma
Published in
Journal for Immunotherapy of Cancer, July 2014
DOI 10.1186/2051-1426-2-21
Pubmed ID
Authors

Minghui Li, Aaron R Bolduc, Md Nasrul Hoda, Denise N Gamble, Sarah-Bianca Dolisca, Anna K Bolduc, Kelly Hoang, Claire Ashley, David McCall, Amyn M Rojiani, Bernard L Maria, Olivier Rixe, Tobey J MacDonald, Peter S Heeger, Andrew L Mellor, David H Munn, Theodore S Johnson

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an enzyme with immune-suppressive properties that is commonly exploited by tumors to evade immune destruction. Anti-tumor T cell responses can be initiated in solid tumors, but are immediately suppressed by compensatory upregulation of immunological checkpoints, including IDO. In addition to these known effects on the adaptive immune system, we previously showed widespread, T cell-dependent complement deposition during allogeneic fetal rejection upon maternal treatment with IDO-blockade. We hypothesized that IDO protects glioblastoma from the full effects of chemo-radiation therapy by preventing vascular activation and complement-dependent tumor destruction.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Belgium 1 1%
Unknown 96 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 29%
Student > Ph. D. Student 21 21%
Student > Bachelor 10 10%
Student > Master 4 4%
Other 3 3%
Other 7 7%
Unknown 25 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 22%
Medicine and Dentistry 17 17%
Chemistry 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Immunology and Microbiology 5 5%
Other 13 13%
Unknown 30 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2022.
All research outputs
#6,373,276
of 25,373,627 outputs
Outputs from Journal for Immunotherapy of Cancer
#1,514
of 3,421 outputs
Outputs of similar age
#55,767
of 240,374 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#3
of 10 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,374 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.