Title |
The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma
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Published in |
Journal for Immunotherapy of Cancer, July 2014
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DOI | 10.1186/2051-1426-2-21 |
Pubmed ID | |
Authors |
Minghui Li, Aaron R Bolduc, Md Nasrul Hoda, Denise N Gamble, Sarah-Bianca Dolisca, Anna K Bolduc, Kelly Hoang, Claire Ashley, David McCall, Amyn M Rojiani, Bernard L Maria, Olivier Rixe, Tobey J MacDonald, Peter S Heeger, Andrew L Mellor, David H Munn, Theodore S Johnson |
Abstract |
Indoleamine 2,3-dioxygenase (IDO) is an enzyme with immune-suppressive properties that is commonly exploited by tumors to evade immune destruction. Anti-tumor T cell responses can be initiated in solid tumors, but are immediately suppressed by compensatory upregulation of immunological checkpoints, including IDO. In addition to these known effects on the adaptive immune system, we previously showed widespread, T cell-dependent complement deposition during allogeneic fetal rejection upon maternal treatment with IDO-blockade. We hypothesized that IDO protects glioblastoma from the full effects of chemo-radiation therapy by preventing vascular activation and complement-dependent tumor destruction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 96 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 28 | 29% |
Student > Ph. D. Student | 21 | 21% |
Student > Bachelor | 10 | 10% |
Student > Master | 4 | 4% |
Other | 3 | 3% |
Other | 7 | 7% |
Unknown | 25 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 22 | 22% |
Medicine and Dentistry | 17 | 17% |
Chemistry | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Immunology and Microbiology | 5 | 5% |
Other | 13 | 13% |
Unknown | 30 | 31% |