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Alzheimer’s disease prevention: from risk factors to early intervention

Overview of attention for article published in Alzheimer's Research & Therapy, September 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)

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811 Mendeley
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Title
Alzheimer’s disease prevention: from risk factors to early intervention
Published in
Alzheimer's Research & Therapy, September 2017
DOI 10.1186/s13195-017-0297-z
Pubmed ID
Authors

Marta Crous-Bou, Carolina Minguillón, Nina Gramunt, José Luis Molinuevo

Abstract

Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a healthcare burden of epidemic proportions for which there is currently no cure. Disappointing results from clinical trials performed in mild-moderate AD dementia combined with clear epidemiological evidence on AD risk factors are contributing to the development of primary prevention initiatives. In addition, the characterization of the long asymptomatic stage of AD is allowing the development of intervention studies and secondary prevention programmes on asymptomatic at-risk individuals, before substantial irreversible neuronal dysfunction and loss have occurred, an approach that emerges as highly relevant.In this manuscript, we review current strategies for AD prevention, from primary prevention strategies based on identifying risk factors and risk reduction, to secondary prevention initiatives based on the early detection of the pathophysiological hallmarks and intervention at the preclinical stage of the disease. Firstly, we summarize the evidence on several AD risk factors, which are the rationale for the establishment of primary prevention programmes as well as revising current primary prevention strategies. Secondly, we review the development of public-private partnerships for disease prevention that aim to characterize the AD continuum as well as serving as platforms for secondary prevention trials. Finally, we summarize currently ongoing clinical trials recruiting participants with preclinical AD or a higher risk for the onset of AD-related cognitive impairment.The growing body of research on the risk factors for AD and its preclinical stage is favouring the development of AD prevention programmes that, by delaying the onset of Alzheimer's dementia for only a few years, would have a huge impact on public health.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 811 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 811 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 197 24%
Student > Master 101 12%
Student > Ph. D. Student 75 9%
Researcher 70 9%
Student > Doctoral Student 35 4%
Other 79 10%
Unknown 254 31%
Readers by discipline Count As %
Neuroscience 96 12%
Medicine and Dentistry 85 10%
Biochemistry, Genetics and Molecular Biology 77 9%
Pharmacology, Toxicology and Pharmaceutical Science 49 6%
Psychology 44 5%
Other 178 22%
Unknown 282 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2021.
All research outputs
#1,065,741
of 21,399,109 outputs
Outputs from Alzheimer's Research & Therapy
#122
of 1,103 outputs
Outputs of similar age
#23,810
of 291,388 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 1 outputs
Altmetric has tracked 21,399,109 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,388 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them