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The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2

Overview of attention for article published in Cell Division, March 2011
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1 peer review site

Citations

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11 Mendeley
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Title
The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
Published in
Cell Division, March 2011
DOI 10.1186/1747-1028-6-7
Pubmed ID
Authors

Agnieszka Lass, Ross Cocklin, Kenneth M Scaglione, Michael Skowyra, Sergey Korolev, Mark Goebl, Dorota Skowyra

Abstract

The S73/S97/loop motif is a hallmark of the Cdc34 family of E2 ubiquitin-conjugating enzymes that together with the SCF E3 ubiquitin ligases promote degradation of proteins involved in cell cycle and growth regulation. The inability of the loop-less Δ12Cdc34 mutant to support growth was linked to its inability to catalyze polyubiquitination. However, the loop-less triple mutant (tm) Cdc34, which not only lacks the loop but also contains the S73K and S97D substitutions typical of the K73/D97/no loop motif present in other E2s, supports growth. Whether tmCdc34 supports growth despite defective polyubiquitination, or the S73K and S97D substitutions, directly or indirectly, correct the defect caused by the loop absence, are unknown.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 27%
Researcher 2 18%
Professor 2 18%
Other 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 45%
Biochemistry, Genetics and Molecular Biology 4 36%
Chemistry 1 9%
Unknown 1 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2016.
All research outputs
#15,303,056
of 22,758,963 outputs
Outputs from Cell Division
#76
of 131 outputs
Outputs of similar age
#85,211
of 109,402 outputs
Outputs of similar age from Cell Division
#2
of 2 outputs
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So far Altmetric has tracked 131 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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