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Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

Overview of attention for article published in Genome Medicine, January 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

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1 tweeter
patent
2 patents

Citations

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61 Dimensions

Readers on

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42 Mendeley
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Title
Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
Published in
Genome Medicine, January 2011
DOI 10.1186/gm273
Pubmed ID
Authors

Katherine R Smith, Vijayaprakash Suppiah, Kate O'Connor, Thomas Berg, Martin Weltman, Maria Abate, Ulrich Spengler, Margaret Bassendine, Gail Matthews, William L Irving, Elizabeth Powell, Stephen Riordan, Golo Ahlenstiel, Graeme J Stewart, Melanie Bahlo, Jacob George, David R Booth

Abstract

The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many. Standard of care therapy is currently pegylated interferon alpha and ribavirin (PegIFN/R), which is effective in less than half of those infected with the most common viral genotype. Two IL28B single nucleotide polymorphisms (SNPs), rs8099917 and rs12979860, predict response to (PegIFN/R) therapy in treatment of HCV infection. These SNPs were identified in genome wide analyses using Illumina genotyping chips. In people of European ancestry, there are 6 common (more than 1%) haplotypes for IL28B, one tagged by the rs8099917 minor allele, four tagged by rs12979860.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Italy 1 2%
Brazil 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Professor > Associate Professor 6 14%
Student > Ph. D. Student 5 12%
Student > Master 5 12%
Other 3 7%
Other 11 26%
Unknown 3 7%
Readers by discipline Count As %
Medicine and Dentistry 15 36%
Agricultural and Biological Sciences 14 33%
Biochemistry, Genetics and Molecular Biology 6 14%
Immunology and Microbiology 2 5%
Social Sciences 1 2%
Other 1 2%
Unknown 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2013.
All research outputs
#6,445,537
of 21,324,218 outputs
Outputs from Genome Medicine
#1,020
of 1,355 outputs
Outputs of similar age
#36,098
of 113,164 outputs
Outputs of similar age from Genome Medicine
#6
of 6 outputs
Altmetric has tracked 21,324,218 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,355 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.9. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,164 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.