Title |
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver
|
---|---|
Published in |
BMC Cancer, July 2014
|
DOI | 10.1186/1471-2407-14-518 |
Pubmed ID | |
Authors |
Alexandra Naba, Karl R Clauser, Charles A Whittaker, Steven A Carr, Kenneth K Tanabe, Richard O Hynes |
Abstract |
Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major component of the tumor microenvironment, is an important contributor to tumor progression. In order to identify candidate biomarkers, we sought to define ECM signatures of metastatic colorectal cancers and their metastases to the liver. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 33% |
United Kingdom | 1 | 17% |
United States | 1 | 17% |
Portugal | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Scientists | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 2 | 1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Unknown | 192 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 26% |
Researcher | 46 | 23% |
Student > Bachelor | 16 | 8% |
Student > Master | 16 | 8% |
Student > Postgraduate | 8 | 4% |
Other | 23 | 12% |
Unknown | 38 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 50 | 25% |
Agricultural and Biological Sciences | 39 | 20% |
Medicine and Dentistry | 23 | 12% |
Engineering | 14 | 7% |
Immunology and Microbiology | 9 | 5% |
Other | 21 | 11% |
Unknown | 43 | 22% |