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Rationale and design of the myocardial microinjury and cardiac remodeling extension study in the sodium lowering in dialysate trial (Mac-SoLID study)

Overview of attention for article published in BMC Nephrology, July 2014
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Title
Rationale and design of the myocardial microinjury and cardiac remodeling extension study in the sodium lowering in dialysate trial (Mac-SoLID study)
Published in
BMC Nephrology, July 2014
DOI 10.1186/1471-2369-15-120
Pubmed ID
Authors

Joanna Leigh Dunlop, Alain Charles Vandal, Janak Rashme de Zoysa, Ruvin Sampath Gabriel, Lukas Mathias Gerber, Imad Adbi Haloob, Christopher John Hood, John Hamilton Irvine, Philip James Matheson, David Owen Ross McGregor, Kannaiyan Samuel Rabindranath, John Benedict William Schollum, David John Semple, Mark Roger Marshall

Abstract

The Sodium Lowering in Dialysate (SoLID) trial is an ongoing a multi-center, prospective, randomised, single-blind (assessor), controlled, parallel assignment clinical trial, enrolling 96 home and self-care hemodialysis (HD) patients from 7 centers in New Zealand. The trial will evaluate the hypothesis that lower dialysate [Na+] during HD results in lower left ventricular (LV) mass. Since it's inception, observational evidence has suggested increased mortality risk with lower dialysate [Na+], possibly due to exacerbation of intra-dialytic hypotension and subsequent myocardial micro-injury. The Myocardial Micro-injury and Cardiac Remodeling Extension Study in the Sodium Lowering In Dialysate Trial (Mac-SoLID study) aims to determine whether lower dialysate [Na+] results in (i) increased levels of high-sensitivity Troponin T (hsTnT), a well-established marker of intra-dialytic myocardial micro-injury in HD populations, and (ii) increased fixed LV segmental wall motion abnormalities, a marker of recurrent myocardial stunning and micro-injury, and (iii) detrimental changes in LV geometry due to maladaptive homeostatic mechanisms.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 26%
Student > Bachelor 5 15%
Researcher 4 12%
Student > Doctoral Student 2 6%
Student > Ph. D. Student 2 6%
Other 1 3%
Unknown 11 32%
Readers by discipline Count As %
Medicine and Dentistry 12 35%
Nursing and Health Professions 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Engineering 2 6%
Sports and Recreations 1 3%
Other 3 9%
Unknown 11 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2014.
All research outputs
#17,723,634
of 22,758,963 outputs
Outputs from BMC Nephrology
#1,698
of 2,462 outputs
Outputs of similar age
#154,482
of 228,570 outputs
Outputs of similar age from BMC Nephrology
#42
of 59 outputs
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