Title |
Rationale and design of the myocardial microinjury and cardiac remodeling extension study in the sodium lowering in dialysate trial (Mac-SoLID study)
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Published in |
BMC Nephrology, July 2014
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DOI | 10.1186/1471-2369-15-120 |
Pubmed ID | |
Authors |
Joanna Leigh Dunlop, Alain Charles Vandal, Janak Rashme de Zoysa, Ruvin Sampath Gabriel, Lukas Mathias Gerber, Imad Adbi Haloob, Christopher John Hood, John Hamilton Irvine, Philip James Matheson, David Owen Ross McGregor, Kannaiyan Samuel Rabindranath, John Benedict William Schollum, David John Semple, Mark Roger Marshall |
Abstract |
The Sodium Lowering in Dialysate (SoLID) trial is an ongoing a multi-center, prospective, randomised, single-blind (assessor), controlled, parallel assignment clinical trial, enrolling 96 home and self-care hemodialysis (HD) patients from 7 centers in New Zealand. The trial will evaluate the hypothesis that lower dialysate [Na+] during HD results in lower left ventricular (LV) mass. Since it's inception, observational evidence has suggested increased mortality risk with lower dialysate [Na+], possibly due to exacerbation of intra-dialytic hypotension and subsequent myocardial micro-injury. The Myocardial Micro-injury and Cardiac Remodeling Extension Study in the Sodium Lowering In Dialysate Trial (Mac-SoLID study) aims to determine whether lower dialysate [Na+] results in (i) increased levels of high-sensitivity Troponin T (hsTnT), a well-established marker of intra-dialytic myocardial micro-injury in HD populations, and (ii) increased fixed LV segmental wall motion abnormalities, a marker of recurrent myocardial stunning and micro-injury, and (iii) detrimental changes in LV geometry due to maladaptive homeostatic mechanisms. |
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Researcher | 4 | 12% |
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