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DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase

Overview of attention for article published in BMC Microbiology, July 2014
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Title
DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase
Published in
BMC Microbiology, July 2014
DOI 10.1186/1471-2180-14-195
Pubmed ID
Authors

Kohinoor Kaur, Neetu Kumra Taneja, Sakshi Dhingra, Jaya S Tyagi

Abstract

Two-component systems have emerged as compelling targets for antibacterial drug design for a number of reasons including the distinct histidine phosphorylation property of their constituent sensor kinases. The DevR-DevS/DosT two component system of Mycobacterium tuberculosis (M. tb) is essential for survival under hypoxia, a stress associated with dormancy development in vivo. In the present study a combinatorial peptide phage display library was screened for DevS histidine kinase interacting peptides with the aim of isolating inhibitors of DevR-DevS signaling.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 51 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 23%
Researcher 9 17%
Student > Master 8 15%
Student > Bachelor 4 8%
Student > Doctoral Student 3 6%
Other 8 15%
Unknown 8 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 27%
Biochemistry, Genetics and Molecular Biology 13 25%
Immunology and Microbiology 4 8%
Chemistry 4 8%
Medicine and Dentistry 3 6%
Other 4 8%
Unknown 10 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2014.
All research outputs
#3,244,691
of 4,057,236 outputs
Outputs from BMC Microbiology
#621
of 801 outputs
Outputs of similar age
#80,632
of 101,215 outputs
Outputs of similar age from BMC Microbiology
#47
of 55 outputs
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So far Altmetric has tracked 801 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.