Title |
Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers
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Published in |
Journal of Neuroinflammation, July 2014
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DOI | 10.1186/1742-2094-11-133 |
Pubmed ID | |
Authors |
Blanca Rojas, Beatriz I Gallego, Ana I Ramírez, Juan J Salazar, Rosa de Hoz, Francisco J Valiente-Soriano, Marcelino Avilés-Trigueros, Maria P Villegas-Perez, Manuel Vidal-Sanz, Alberto Triviño, José M Ramírez |
Abstract |
Glaucomatous optic neuropathy, a leading cause of blindness, can progress despite control of intraocular pressure - currently the main risk factor and target for treatment. Glaucoma progression shares mechanisms with neurodegenerative disease, including microglia activation. In the present model of ocular hypertension (OHT), we have recently described morphological signs of retinal microglia activation and MHC-II upregulation in both the untreated contralateral eyes and OHT eyes. By using immunostaining, we sought to analyze and quantify additional signs of microglia activation and differences depending on the retinal layer. |
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