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Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling

Overview of attention for article published in Epigenetics & Chromatin, July 2014
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Title
Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling
Published in
Epigenetics & Chromatin, July 2014
DOI 10.1186/1756-8935-7-16
Pubmed ID
Authors

Na Xu, Alexander V Emelyanov, Dmitry V Fyodorov, Arthur I Skoultchi

Abstract

Within the nucleus of eukaryotic cells, chromatin is organized into compact, silent regions called heterochromatin and more loosely packaged regions of euchromatin where transcription is more active. Although the existence of heterochromatin has been known for many years, the cellular factors responsible for its formation have only recently been identified. Two key factors involved in heterochromatin formation in Drosophila are the H3 lysine 9 methyltransferase Su(var)3-9 and heterochromatin protein 1 (HP1). The linker histone H1 also plays a major role in heterochromatin formation in Drosophila by interacting with Su(var)3-9 and helping to recruit it to heterochromatin. Drosophila STAT (Signal transducer and activator of transcription) (STAT92E) has also been shown to be involved in the maintenance of heterochromatin, but its relationship to the H1-Su(var)3-9 heterochromatin pathway is unknown. STAT92E is also involved in tumor formation in flies. Hyperactive Janus kinase (JAK)-STAT signaling due to a mutation in Drosophila JAK (Hopscotch) causes hematopoietic tumors.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 5%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 30%
Student > Ph. D. Student 10 25%
Student > Bachelor 4 10%
Student > Master 4 10%
Professor > Associate Professor 2 5%
Other 4 10%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 43%
Biochemistry, Genetics and Molecular Biology 9 23%
Engineering 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Computer Science 1 3%
Other 5 13%
Unknown 5 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2014.
All research outputs
#14,431,072
of 23,577,654 outputs
Outputs from Epigenetics & Chromatin
#401
of 574 outputs
Outputs of similar age
#116,873
of 230,448 outputs
Outputs of similar age from Epigenetics & Chromatin
#4
of 14 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 574 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,448 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.