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Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies

Overview of attention for article published in BMC Bioinformatics, November 2010
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Title
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies
Published in
BMC Bioinformatics, November 2010
DOI 10.1186/1471-2105-11-552
Pubmed ID
Authors

Bo Chen, Minhua Chen, John Paisley, Aimee Zaas, Christopher Woods, Geoffrey S Ginsburg, Alfred Hero, Joseph Lucas, David Dunson, Lawrence Carin

Abstract

Nonparametric Bayesian techniques have been developed recently to extend the sophistication of factor models, allowing one to infer the number of appropriate factors from the observed data. We consider such techniques for sparse factor analysis, with application to gene-expression data from three virus challenge studies. Particular attention is placed on employing the Beta Process (BP), the Indian Buffet Process (IBP), and related sparseness-promoting techniques to infer a proper number of factors. The posterior density function on the model parameters is computed using Gibbs sampling and variational Bayesian (VB) analysis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Brazil 1 1%
Australia 1 1%
Taiwan 1 1%
Israel 1 1%
Unknown 66 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 27%
Researcher 15 20%
Student > Master 9 12%
Student > Bachelor 6 8%
Professor 6 8%
Other 13 18%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 20%
Engineering 9 12%
Computer Science 9 12%
Mathematics 8 11%
Medicine and Dentistry 8 11%
Other 18 24%
Unknown 7 9%