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Characteristics of compounds that cross the blood-brain barrier

Overview of attention for article published in BMC Neurology, June 2009
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 2,711)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
7 news outlets
twitter
10 X users
patent
6 patents
facebook
1 Facebook page
wikipedia
1 Wikipedia page
googleplus
1 Google+ user

Citations

dimensions_citation
549 Dimensions

Readers on

mendeley
1120 Mendeley
citeulike
3 CiteULike
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Title
Characteristics of compounds that cross the blood-brain barrier
Published in
BMC Neurology, June 2009
DOI 10.1186/1471-2377-9-s1-s3
Pubmed ID
Authors

William A Banks

Abstract

Substances cross the blood-brain barrier (BBB) by a variety of mechanisms. These include transmembrane diffusion, saturable transporters, adsorptive endocytosis, and the extracellular pathways. Here, we focus on the chief characteristics of two mechanisms especially important in drug delivery: transmembrane diffusion and transporters. Transmembrane diffusion is non-saturable and depends, on first analysis, on the physicochemical characteristics of the substance. However, brain-to-blood efflux systems, enzymatic activity, plasma protein binding, and cerebral blood flow can greatly alter the amount of the substance crossing the BBB. Transport systems increase uptake of ligands by roughly 10-fold and are modified by physiological events and disease states. Most drugs in clinical use to date are small, lipid soluble molecules that cross the BBB by transmembrane diffusion. However, many drug delivery strategies in development target peptides, regulatory proteins, oligonucleotides, glycoproteins, and enzymes for which transporters have been described in recent years. We discuss two examples of drug delivery for newly discovered transporters: that for phosphorothioate oligonucleotides and for enzymes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 6 <1%
United States 5 <1%
United Kingdom 3 <1%
Spain 2 <1%
India 2 <1%
Brazil 1 <1%
Italy 1 <1%
Portugal 1 <1%
China 1 <1%
Other 3 <1%
Unknown 1095 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 239 21%
Student > Bachelor 147 13%
Student > Master 145 13%
Researcher 133 12%
Student > Doctoral Student 52 5%
Other 153 14%
Unknown 251 22%
Readers by discipline Count As %
Chemistry 154 14%
Agricultural and Biological Sciences 141 13%
Biochemistry, Genetics and Molecular Biology 123 11%
Medicine and Dentistry 112 10%
Pharmacology, Toxicology and Pharmaceutical Science 109 10%
Other 202 18%
Unknown 279 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2024.
All research outputs
#601,503
of 25,552,933 outputs
Outputs from BMC Neurology
#31
of 2,711 outputs
Outputs of similar age
#1,454
of 123,328 outputs
Outputs of similar age from BMC Neurology
#3
of 10 outputs
Altmetric has tracked 25,552,933 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,711 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.