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Advances in understanding the cell types and approaches used for generating induced pluripotent stem cells

Overview of attention for article published in Journal of Hematology & Oncology, July 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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1 blog
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2 X users

Citations

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37 Dimensions

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93 Mendeley
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Title
Advances in understanding the cell types and approaches used for generating induced pluripotent stem cells
Published in
Journal of Hematology & Oncology, July 2014
DOI 10.1186/s13045-014-0050-z
Pubmed ID
Authors

Jun Li, Wei Song, Guangjin Pan, Jun Zhou

Abstract

Successfully reprogramming somatic cells to a pluripotent state generates induced pluripotent stem (iPS) cells (or iPSCs), which have extensive self-renewal capacity like embryonic stem cells (ESCs). iPSCs can also generate daughter cells that can further undergo differentiation into various lineages or terminally differentiate to reach their final functional state. The discovery of how to produce iPSCs opened a new field of stem cell research with both intellectual and therapeutic benefits. The huge potential implications of disease-specific or patient-specific iPSCs have impelled scientists to solve problems hindering their applications in clinical medicine, especially the issues of convenience and safety. To determine the range of tissue types amenable to reprogramming as well as their particular characteristics, cells from three embryonic germ layers have been assessed, and the advantages that some tissue origins have over fibroblast origins concerning efficiency and accessibility have been elucidated. To provide safe iPSCs in an efficient and convenient way, the delivery systems and combinations of inducing factors as well as the chemicals used to generate iPSCs have also been significantly improved in addition to the efforts on finding better donor cells. Currently, iPSCs can be generated without c-Myc and Klf4 oncogenes, and non-viral delivery integration-free chemically mediated reprogramming methods have been successfully employed with relatively satisfactory efficiency. This paper will review recent advances in iPS technology by highlighting tissue origin and generation of iPSCs. The obstacles that need to be overcome for clinical applications of iPSCs are also discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Spain 1 1%
United States 1 1%
Colombia 1 1%
Unknown 89 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 24%
Student > Master 18 19%
Researcher 14 15%
Student > Bachelor 11 12%
Professor 4 4%
Other 9 10%
Unknown 15 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 35%
Biochemistry, Genetics and Molecular Biology 17 18%
Medicine and Dentistry 11 12%
Neuroscience 3 3%
Engineering 3 3%
Other 7 8%
Unknown 19 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2014.
All research outputs
#3,652,191
of 22,759,618 outputs
Outputs from Journal of Hematology & Oncology
#271
of 1,189 outputs
Outputs of similar age
#36,701
of 228,924 outputs
Outputs of similar age from Journal of Hematology & Oncology
#2
of 9 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,189 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.