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First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

Overview of attention for article published in Alzheimer's Research & Therapy, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
1 tweeter
patent
3 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
163 Dimensions

Readers on

mendeley
193 Mendeley
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Title
First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
Published in
Alzheimer's Research & Therapy, January 2014
DOI 10.1186/alzrt278
Pubmed ID
Authors

Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Petr Novak, Michal Novak

Abstract

We have identified structural determinants on tau protein that are essential for pathological tau-tau interaction in Alzheimer's disease (AD). These regulatory domains, revealed by monoclonal antibody DC8E8, represent a novel target for tau-directed therapy. In order to validate this target, we have developed an active vaccine, AADvac1.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 1%
United States 1 <1%
Unknown 190 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 44 23%
Researcher 35 18%
Student > Master 32 17%
Student > Ph. D. Student 25 13%
Student > Postgraduate 11 6%
Other 18 9%
Unknown 28 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 18%
Neuroscience 32 17%
Biochemistry, Genetics and Molecular Biology 27 14%
Medicine and Dentistry 21 11%
Pharmacology, Toxicology and Pharmaceutical Science 15 8%
Other 28 15%
Unknown 35 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2021.
All research outputs
#947,591
of 21,200,954 outputs
Outputs from Alzheimer's Research & Therapy
#107
of 1,090 outputs
Outputs of similar age
#10,585
of 208,623 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 1 outputs
Altmetric has tracked 21,200,954 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,090 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them