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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients
|
|---|---|
| Published in |
Critical Care, August 2014
|
| DOI | 10.1186/cc14003 |
| Pubmed ID | |
| Authors |
Christabelle J Darcy, Gabriela Minigo, Kim A Piera, Joshua S Davis, Yvette R McNeil, Youwei Chen, Alicia D Volkheimer, J Brice Weinberg, Nicholas M Anstey, Tonia Woodberry |
| Abstract |
Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell receptor CD3 zeta-chain expression and T cell function and are linked to poor clinical outcome, but their role during acute human infectious disease and in particular sepsis remains unknown. Hypoarginemia is prevalent in sepsis. This study aimed to determine whether neutrophils that co-purify with PBMC express arginase, and if arginine depletion constrains T cell CD3 zeta-chain expression and function in human sepsis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 3 | 2% |
| Sweden | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 119 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 19% |
| Researcher | 20 | 16% |
| Student > Master | 17 | 14% |
| Student > Bachelor | 14 | 11% |
| Student > Doctoral Student | 8 | 6% |
| Other | 15 | 12% |
| Unknown | 26 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 27% |
| Immunology and Microbiology | 23 | 19% |
| Agricultural and Biological Sciences | 21 | 17% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 7 | 6% |
| Unknown | 31 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2017.
All research outputs
#3,202,446
of 25,374,917 outputs
Outputs from Critical Care
#2,616
of 6,554 outputs
Outputs of similar age
#30,885
of 240,212 outputs
Outputs of similar age from Critical Care
#32
of 124 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,212 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.