Title |
Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection
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Published in |
AIDS Research and Therapy, August 2014
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DOI | 10.1186/1742-6405-11-23 |
Pubmed ID | |
Authors |
Milan Raska, Lydie Czernekova, Zina Moldoveanu, Katerina Zachova, Matt C Elliott, Zdenek Novak, Stacy Hall, Michael Hoelscher, Leonard Maboko, Rhubell Brown, Phillip D Smith, Jiri Mestecky, Jan Novak |
Abstract |
HIV-1 entry into host cells is mediated by interactions between the virus envelope glycoprotein (gp120/gp41) and host-cell receptors. N-glycans represent approximately 50% of the molecular mass of gp120 and serve as potential antigenic determinants and/or as a shield against immune recognition. We previously reported that N-glycosylation of recombinant gp120 varied, depending on the producer cells, and the glycosylation variability affected gp120 recognition by serum antibodies from persons infected with HIV-1 subtype B. However, the impact of gp120 differential glycosylation on recognition by broadly neutralizing monoclonal antibodies or by polyclonal antibodies of individuals infected with other HIV-1 subtypes is unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 20% |
United States | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Spain | 1 | 2% |
United States | 1 | 2% |
Turkey | 1 | 2% |
Unknown | 50 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 22% |
Researcher | 11 | 20% |
Student > Master | 8 | 15% |
Student > Bachelor | 6 | 11% |
Student > Postgraduate | 3 | 6% |
Other | 5 | 9% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 33% |
Biochemistry, Genetics and Molecular Biology | 10 | 19% |
Medicine and Dentistry | 5 | 9% |
Immunology and Microbiology | 4 | 7% |
Nursing and Health Professions | 2 | 4% |
Other | 4 | 7% |
Unknown | 11 | 20% |