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Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection

Overview of attention for article published in AIDS Research and Therapy, August 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
1 blog
twitter
5 X users
patent
1 patent

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
54 Mendeley
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Title
Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection
Published in
AIDS Research and Therapy, August 2014
DOI 10.1186/1742-6405-11-23
Pubmed ID
Authors

Milan Raska, Lydie Czernekova, Zina Moldoveanu, Katerina Zachova, Matt C Elliott, Zdenek Novak, Stacy Hall, Michael Hoelscher, Leonard Maboko, Rhubell Brown, Phillip D Smith, Jiri Mestecky, Jan Novak

Abstract

HIV-1 entry into host cells is mediated by interactions between the virus envelope glycoprotein (gp120/gp41) and host-cell receptors. N-glycans represent approximately 50% of the molecular mass of gp120 and serve as potential antigenic determinants and/or as a shield against immune recognition. We previously reported that N-glycosylation of recombinant gp120 varied, depending on the producer cells, and the glycosylation variability affected gp120 recognition by serum antibodies from persons infected with HIV-1 subtype B. However, the impact of gp120 differential glycosylation on recognition by broadly neutralizing monoclonal antibodies or by polyclonal antibodies of individuals infected with other HIV-1 subtypes is unknown.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
United States 1 2%
Turkey 1 2%
Unknown 50 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 22%
Researcher 11 20%
Student > Master 8 15%
Student > Bachelor 6 11%
Student > Postgraduate 3 6%
Other 5 9%
Unknown 9 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 33%
Biochemistry, Genetics and Molecular Biology 10 19%
Medicine and Dentistry 5 9%
Immunology and Microbiology 4 7%
Nursing and Health Professions 2 4%
Other 4 7%
Unknown 11 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2023.
All research outputs
#3,026,495
of 25,374,917 outputs
Outputs from AIDS Research and Therapy
#58
of 637 outputs
Outputs of similar age
#29,238
of 240,212 outputs
Outputs of similar age from AIDS Research and Therapy
#1
of 16 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 637 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,212 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.