Title |
Trans-cranial opening of the blood-brain barrier in targeted regions using astereotaxic brain atlas and focused ultrasound energy
|
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Published in |
Journal of Therapeutic Ultrasound, August 2014
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DOI | 10.1186/2050-5736-2-13 |
Pubmed ID | |
Authors |
Chenchen Bing, Michelle Ladouceur-Wodzak, Clinton R Wanner, John M Shelton, James A Richardson, Rajiv Chopra |
Abstract |
The blood-brain barrier (BBB) protects the brain by preventing the entry of large molecules; this poses a major obstacle for the delivery of drugs to the brain. A novel technique using focused ultrasound (FUS) energy combined with microbubble contrast agents has been widely used for non-invasive trans-cranial BBB opening. Traditionally, FUS research is conducted with magnetic resonance imaging (MRI) guidance, which is expensive and poses physical limitations due to the magnetic field. A system that could allow researchers to test brain therapies without MR intervention could facilitate and accelerate translational research. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 1% |
Unknown | 79 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 24% |
Student > Ph. D. Student | 18 | 23% |
Student > Master | 11 | 14% |
Professor > Associate Professor | 5 | 6% |
Student > Postgraduate | 4 | 5% |
Other | 8 | 10% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
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Engineering | 22 | 28% |
Medicine and Dentistry | 11 | 14% |
Agricultural and Biological Sciences | 11 | 14% |
Physics and Astronomy | 5 | 6% |
Neuroscience | 5 | 6% |
Other | 8 | 10% |
Unknown | 18 | 23% |