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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nestin expression in mesenchymal stromal cells: regulation by hypoxia and osteogenesis
|
|---|---|
| Published in |
BMC Veterinary Research, August 2014
|
| DOI | 10.1186/s12917-014-0173-z |
| Pubmed ID | |
| Authors |
Alice Wong, Ehssan Ghassemi, Clare E Yellowley |
| Abstract |
The intermediate filament protein nestin is used as a marker for neural stem cells, and its expression is inversely correlated with cellular differentiation. More recently, nestin expression has also been described in other cell types including multipotential mesenchymal stromal cells (MSCs). In this study, we examined the expression of nestin in equine, canine and human bone marrow-derived MSCs undergoing osteogenic differentiation, to determine whether nestin levels were attenuated as the cells acquired a more mature phenotype. In addition, the expression of nestin may be under the influence of cellular hypoxia, as nestin expression is known to increase in areas of ischemic tissue damage. Therefore, we also examined the effects of hypoxia on expression of nestin in human MSCs and examined a role for hypoxia inducible factor 1-alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in the response. Additionally, we quantified the temporal expression of nestin in the fracture callus during bone regeneration, a site that has been characterized as hypoxic. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 32% |
| Student > Master | 7 | 12% |
| Researcher | 6 | 10% |
| Student > Doctoral Student | 4 | 7% |
| Student > Bachelor | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 12 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 29% |
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Veterinary Science and Veterinary Medicine | 5 | 8% |
| Agricultural and Biological Sciences | 5 | 8% |
| Neuroscience | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 13 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2014.
All research outputs
#18,375,478
of 22,759,618 outputs
Outputs from BMC Veterinary Research
#1,915
of 3,042 outputs
Outputs of similar age
#164,198
of 230,115 outputs
Outputs of similar age from BMC Veterinary Research
#27
of 44 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,042 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,115 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.