Title |
Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study
|
---|---|
Published in |
Arthritis Research & Therapy, October 2013
|
DOI | 10.1186/ar4350 |
Pubmed ID | |
Authors |
Dinny Wallis, Arundip Asaduzzaman, Michael Weisman, Nigil Haroon, Ammepa Anton, Dermot McGovern, Stephan Targan, Robert Inman |
Abstract |
Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share genetic and clinical features. IBD is associated with the presence of antibodies to a variety of commensal microorganisms including anti-Saccharomyces cerevesiae antibodies (ASCA), antineutrophil cytoplasmic antibodies (ANCA), anti-I2 (associated with anti-Pseudomonas activity), anti-Eschericia coli outer membrane porin C (anti-OmpC) and anti-flagellin antibodies (anti-CBir1). Subclinical intestinal inflammation may be present in up to 65% of patients with AS. This study evaluated the presence of antimicrobial antibodies in patients with AS alone, patients with AS and concomitant IBD (AS-IBD) and a control group of patients with mechanical back pain (MBP). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Greece | 1 | 2% |
Unknown | 55 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 16% |
Student > Ph. D. Student | 8 | 14% |
Researcher | 7 | 12% |
Student > Doctoral Student | 6 | 10% |
Other | 6 | 10% |
Other | 12 | 21% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 48% |
Agricultural and Biological Sciences | 8 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Immunology and Microbiology | 3 | 5% |
Unspecified | 1 | 2% |
Other | 2 | 3% |
Unknown | 12 | 21% |